Hyperpolarization-relaxation coupling in vascular smooth muscle.
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منابع مشابه
Heme oxygenase-mediated vasodilation involves vascular smooth muscle cell hyperpolarization.
Chronic hypoxia is associated with both blunted agonist-induced and myogenic vascular reactivity and is possibly due to an enhanced production of heme oxygenase (HO)-derived carbon monoxide (CO). However, the mechanism of endogenous CO-meditated vasodilation remains unclear. Isolated pressurized mesenteric arterioles from chronically hypoxic rats were administered the HO substrate heme-l-lysina...
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The activation of soluble guanylate cyclase (sGC) by nitric oxide (NO) and other ligands has been extensively investigated for many years. In the present study we considered the effect of molecular oxygen (O2) on sGC both as a direct ligand and its affect on other ligands by measuring cyclic guanosine monophosphate (cGMP) production, as an index of activity, as well as investigating smooth musc...
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In vascular smooth muscles, neurotransmitters or autacoids produce contraction through activation of Ca2(+)-influx and release of Ca2+ from intracellular store sites. These agonists appear to activate Ca2(+)-influxes in both voltage-dependent and voltage-independent manners. The release of Ca2+ is though to be linked to the action of inositol 1,4,5-trisphosphate. The phosphorylation of myosin l...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1995
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.106.157